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WHAT DOES A STEM CELL TREATMENT TYPICALLY COST?

In today’s world of regenerative/stem cell medicine, there are numerous types of products out there in the market and it can be extremely confusing to the normal everyday person with no medical or scientific background, especially to understand the true stem cell therapy cost.  You have unscrupulous clinics marketing amniotic products, cord blood products, and placental products as “stem cell” treatments when in essence there are no “live” cells in these products. These unscrupulous casts of characters typically prey on older patients that are looking for these treatments and the sales pitch is that these cells are “younger” and will work much better.  The reality is that this is not a true statement since the aforementioned products contain no “live” cells. For these types of procedures, the cost can vary from $5,000 to $8000 for joint injection.

For an “autologous” (meaning cells derived from the patient’s own tissue) stem cell treatment prices can vary from $5000 to $8000 for a single treatment.  There are more comprehensive stem cell treatments that need to be performed in a hospital and these can run up $25,000 and more.

Autologous stem cell therapies use live human cells that are harvested from the patient and used that vary same day.  The tissue that is used whether it is Adipose Tissue (Fat Tissue), Bone Marrow, or Peripheral Blood it must go through a protocol that normally consists of harvesting, isolate and activate the stem cells, and finally application which is typically localized injection or intravenous to start the healing process and treat disease.

The patient in order to receive one of these treatments most go through some very basic steps.  The first step is a complete medical evaluation, extraction of tissue, blood, or bone marrow, application of the stem cells, post op monitoring with monthly follow ups. There are many costs involved for the physician when it comes to these therapies.  Doctors must have training in whatever protocol they chose to use and that has a cost of $3,000 to $10,000 depending on the training program. The physician in addition has costs lab space, lab equipment, kits, office medical staff, Malpractice Insurance, and admin costs. These protocols are very labor intensive and take 3-4 hours and the patient stays in the Doctor’s office usually the entire day.

Over the past decade, the field of regenerative medicine and adult stem cell treatments are gaining more and more popularity. Unfortunately, there are very few reputable companies in the United States that perform these treatments properly.   Studies on the topic have also increased substantially with over 300,000 available to review and clinical trials are close to 5,000.

You would think that with the growing interest and the fact that stem cell clinics are popping up all over the United States prices would level off just because of basic supply and demand, however this is not the case. The most simple and accessible option is obtaining the cells from the bone marrow, secondly peripheral blood, and lastly adipose tissue.  Still due to factors mentioned above the average costs can still range from $5,000 to $8,000 for localized orthopedic injections, such as knee, shoulders, hips, and back.

Since these procedures are not FDA approved, reason being the FDA has nothing to approve if you are using the patient's own cells and there is no drug involved.  Remember the FDA stands for The Food and “DRUG” Administration, insurance companies will not shell out any monies for these treatments. Since autologous stem cell treatments are considered experimental, the patient must pay out of pocket.

There is a big push from academics and Big Pharma to make these treatments illegal.  There is nothing to patent therefore no money to be made so they are angry! Universities receive large grants from Big Pharma, so they also feel threatened by the fact that hundreds of thousands of patients have received benefits from stem cell treatments they cannot commercialize and fleece the American public.   Therefore, if the FDA and Big Pharma succeed in their quest to continue to hurt the American public in order to make a profit, American patients will be forced to go abroad to receive these treatments and end up paying far more.

According to a poll conducted by Bioinformant 30% of respondents spent $5,000.00 or less on stem cell treatments; 20% spent $5-10,000; 40% spent $10-25,000; and 10% spent over $25,000.00. Those that spent less than $5,000.00 were most likely pursuing treatment of orthopedic or musculoskeletal conditions. Those paying higher were most likely pursuing treatments for systemic or more complex conditions such as multiple sclerosis, diabetes, and neurodegenerative diseases.

Stem Cell protocols vary from clinic to clinic depending on the training of that specific Doctor. One-time peripheral blood stem cell treatments can be as little as $1,900 and protocols utilizing bone marrow or fat tissue can run $15,000-$30,000.

Systemic or whole body approaches of treatment tend to have costs in higher ranges most often averaging $20-30,000.00 or more; these treatments can be for such diseases as multiple sclerosis, Crohn’s disease, psoriatic or rheumatoid arthritis, and neurodegenerative disease like dementia and Alzheimer’s disease. Higher costs reflect complexity of treatments and multiple treatments being required.

There is no evidence pointing to clinics raising costs as a result of lawsuits, but this is a typical industry response for high risk services with reduction of bottom line profits through lawsuits. Depending where treatment is received patients may also have to pay for travel and lodging.

Cost of stem cell therapy may seem expensive, however those who using this option feel it is more economical than enduring costs associated with chronic disease. Cost alone should never be the deciding factor in stem cell therapies.  The clinics reputation, physician’s reputation, physician training, and patient results should also be highly considered.

These treatments though they are not cheap the benefits can clearly surpass the costs.  Living with a chronic disease is not a fun experience and prescription medicine can be very expensive over time.  Stem Cell treatments are more than proven to have help hundreds of thousands perhaps millions around the world today.  Stem Cell and Regenerative medicine is here today, and patients should have this option available to them.

The American people need to be aware and educate themselves in stem cell therapies.  The FDA and Big Pharma are looking to close the door on the future of medicine and make it impossible for  a physician to carry out these procedures.

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The Cost Of Stem Cell Therapy in 2022

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Stem Cell Therapy Vs. Platelet Rich Plasma Therapy

An introduction

Imagine a situation where you could cause an injury to heal naturally? Or you could cause damaged tissues and organs to heal naturally. This would make a great difference in your life wouldn’t’ it? This would results in more natural healing of injuries and chronic diseases. Regenerative medicine including stem cell therapy and platelet rich therapy makes this possible, and this appears to be the future of medicine.

Many case studies have testified to the effectiveness of stem cell therapy. It is effective for all ailments ranging from spinal stenosis, herniated discs, damage of the knee ligament, to torn rotator cuffs. Stem cell therapy can do virtually everything.

Some interesting research and case studies have been carried out in the United States, Mexico, Panama, and Ukraine. It therefore appears that medicine has a bright future if any tissue or cell can be regenerated.

What is platelet-rich plasma?

Platelet rich plasma is known informally as PRP. It is a non-surgical, and non-invasive therapy that encourages natural healing of the body. Platelet-rich therapy helps with many medical issues, such as:

  • Tendon injuries
  • Hair loss or baldness
  • Minimize inflammation
  • Pulled or sprained muscles
  • Ligament or tendon repair usually after surgery
  • Chronic tendon injuries
  • Osteoarthritis
  • Overuse injuries

Platelet rich plasma therapy involves the drawing of a small amount of blood. The platelets are separated from the serum using a centrifuge. This highly concentrated platelet-rich plasma is the injected into the area that is injured. Risk of side effects associated with platelet-rich therapy is very low. This is owing to the fact that the platelets are derived from the patient’s own blood. Stem cell therapy is also incorporated into some platelet rich plasma therapies.

 

 

About stem cell therapies

Stem cells are basically undifferentiated cells. What this means is that they have the potential to become just any kind of cell. Theoretically, the implication is that injection of stem cells into a person could result in the creation of new cells that will form tissues required to heal the damaged area. Stem cells are of two main categories: embryonic stem cells and adult stem cells.

Embryonic stem cells may develop into any kind of cells. This means that they have a very wide application – much wider than the adult stem cells. Research indicates that the amniotic fluid and umbilical cord blood may be a good resource of embryonic stem cells.

Adult stem cells can be sourced from any part of the body, but in many cases are taken from adipose tissue and the bone marrow. When stem cells are extracted from an adult tissue, they will develop into the parent tissue. Thus, their applications are very limited.

There has been a great deal of development in stem cell medicine. As a matter of fact, scientists have found out that the umbilical cord and the placenta, is rich in viable content for mesenchymal stem cell extraction. Mesenchymal stem cells can differentiate into cells that effectively treat autism, autoimmune diseases, cancer, and a host of other health conditions.

Stem cells derived from adipose tissue have miraculously helped in the treatment of quadriplegics, Amyolateral sclerosis, and a host of other neurological ailments.

 

Their mechanism of action?

Platelet rich therapy works by injecting the body with a very high concentration of the body’s growth and healing factors (up to 10 times the amount), thus hastening the process. Platelets enhance the clotting process, stimulate the production of collagen, and speed up the healing of wounds and regeneration of tissues (ligaments and tendons).

Conversely, stem cell therapy works via stem cell transplant from the donor to repair and regenerate damaged organs or tissues. There is a high risk of the stem cell being rejected during the transplant, hence the need for immune suppressive medications.

The major distinction between platelet rich plasma therapy and stem cell therapy is that the former is derived from the patient’s own body, thus minimizing the risk of rejection, and also avoiding some ethical issues. Also, platelet rich plasma enhances growth and other signals. Conversely, stem cells therapy allows the infusion of fresh cells into the site to enhance growth and regeneration.

 

Any controversy around the two therapies?

The stem cell controversy is due to the fact that the most viable and versatile stem cells come from embryos.  Because it involves human embryos, this area of research has widely debatable ethical implications. In fact, the controversies caused the George Bush led government to cut short the funding for stem cell research for a while.

At the moment, stem cell treatment is used mainly for the treatment of some blood disorders and accident (burn) victims. Some stem cell facilities gave promised to provide treatment for many diseases and injuries, aging inclusive.

 

Is stem cell therapy and platelet rich plasma therapy the future of medicine?

Both platelet rich plasma therapy and stem cell therapy are capable of causing a revolution in the healthcare industry, just as other areas of regenerative medicine. If the hypotheses is backed by further research, then it could cause a great change in the ways in which diseases and injuries are treated.

That notwithstanding, the task at hand revolves around validating the theories, especially that involving the transplantation of embryonic stem cells.  There is more research backing the workability of platelet rich plasma therapy. However, it is yet to be approved by the FDA.

In the field of regenerative medicine, there are endless capabilities and of course, lots of untapped potentials. However, there is need for more research, but the results from clinical trials looks promising.

 

REFERENCES

Marx RE. Platelet-rich plasma: evidence to support its use. J Oral Maxillofac Surg. 2004; 62:489–496

Eppley BL, Pietrzak WS, Blanton M. Platelet-rich plasma: a review of biology and applications in plastic surgery. Plast Reconstr Surg. 2006; 118:147e–159e.

Muehlberg FL, Song YH, Krohn A, et al. Tissue-resident stem cells promote breast cancer growth and metastasis. Carcinogenesis. 2009; 30:589–597

Yu JM, Jun ES, Bae YC, et al. Mesenchymal stem cells derived from human adipose tissues favor tumor cell growth in vivo. Stem Cells Dev. 2008; 17:463–473

Donnenberg VS, Zimmerlin L, Rubin JP, et al. Regenerative therapy after cancer: what are the risks? Tissue Eng Part B Rev. 2010; 16:567–575.

Zimmerlin L, Donnenberg AD, Rubin JP, et al. Regenerative therapy and cancer: in vitro and in vivo studies of the interaction between adipose-derived stem cells and breast cancer cells from clinical isolates. Tissue Eng Part A. 2011; 17:93–106

Jotzu C, Alt E, Welte G, et al. Adipose tissue-derived stem cells differentiate into carcinoma-associated fibroblast-like cells under the influence of tumor-derived factors. Anal Cell Pathol (Amst) 2010; 33:61–79.

Zhao M, Dumur CI, Holt SE, et al. Multipotent adipose stromal cells and breast cancer development: Think globally, act locally. Mol Carcinog. 2010; 49:923–927.

Prantl L, Muehlberg F, Navone NM, et al. Adipose tissue-derived stem cells promote prostate tumor growth. Prostate. 2010; 70:1709–1715.

Hu Z, Peel SA, Ho SK, et al. Platelet-rich plasma induces mRNA expression of VEGF and PDGF in rat bone marrow stromal cell differentiation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009; 107:43–48.

 

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Benefits of Platlet-Rich Plasma (PRP Therapy)

AN OVERVIEW OF PLATELET-RICH PLASMA

Platelet-rich plasma is also known as PRP. It is a substance that enhances healing when injected. The plasma is a blood component containing special proteins or factors that allows the blood to clot. It is also rich in proteins that support the growth of cells. Scientists have artificially produced platelet rich plasma through plasma isolation from the blood, and then subsequent concentration.

It is believed that the injection of platelet-rich plasma stimulates the growth of new and healthy cells in the body, thus promoting healing. Because the tissue growth factors have a higher concentration in the prepared growth injections, scientists believe that the tissues will heal more quickly.

There has been no definite proof to treatment with platelet-rich plasma. As a matter of fact, the US FDA is yet to approve PRP as a treatment. However, renowned athletes like Rafael Nadal and Tiger Woods have used PRP to facilitate healing of injuries.

APPLICATIONS OF PRP INJECTIONS

Scientists are trying out platelet-rich plasma injections across many applications. These include:

Baldness: PRP is injected into the bald scalp to enhance the growth of hair and prevent loss of hair. A 2014 research has shown that platelet-rich plasma injections are very effective for the treatment of androgenic alopecia, also referred to as male pattern baldness.

Tendon injuries: Tendons are tissue that link the muscle to bones. They are tough bands of tissue. Tendons do not heal quickly after an injury. PRP injections have been used by physicians to treat chronic disorders of the tendon such as Achilles tendonitis, tennis elbow, or jumper’s knee.

Acute injuries: Platelet-rich plasma has been used for the treatment of sport injuries such as knee sprains and pulled hamstring muscles.

Osteoarthritis: PRP has been used on patients with osteoarthritis. The mixture is usually injected into the knees. A study conducted in 2015 has found that platelet-rich plasma injections are very effective for the treatment of osteoarthritis, more effective than hyaluronic injections.

Postsurgical repair: PRP injections are sometimes used after surgery to effect repairs on damaged tendons (for example the rotator cuff tendon). It may also be used for repairs of the ligament (like the anterior cruciate ligament).

 

BENEFITS OF PRP THERAPY

Natural and improved healing: Injection of platelet-rich plasma into damaged or injured tissues enhances the process of regeneration for better healing. When done alongside facelift surgery, platelet rich plasma is injected near sutures, into sites of incision, and under the skin to facilitate the healing of tissues and with good results.

Scarring is reduced: PRP therapy is also beneficial to the human through its potential to reduce scarring. This is of immense benefit to those who undergo facelift surgery and want to reduce the visibility of scars.

Recovery is faster: It has been established above, the PRP therapy increases platelet count in the tissues, which can facilitate healing after surgery.

Swelling is reduced: Swelling is reduced when PRP therapy is combined with facelift surgery. This can allow patients witness the results of their treatment much sooner than expected.

Reduction in blood loss: Platelet rich therapy increases the platelet count at the site of injections, thus most PRP beneficiaries do not experience much blood loss.

Bruising is decreased: Bruising results when blood vessels within the skin are injured. These vessels bleed into the tissues, resulting in the purple coloration seen in bruises. However, this issue is addressed by platelet rich therapy which reduces the severity of bruising and blood loss by increasing the number of clotting factors.

 

PREPARING FOR PRP INJECTIONS

Preparing for the PRP injection is not a complex process.

Injection of PRP can be done in a number of ways. For instance, a lidocaine solution (for numbing) may be applied on the scalp prior to the injection. To have this applied, you may have to report early to a treatment session.

In other cases, the PRP is mixed with a local anesthetic to minimize discomfort. In other cases, the physician may inject the PRP during a surgical procedure. Here, preparing for the PRP therapy would involve adopting your surgeon’s pre-surgery recommendations.

 

DOES PRP HAVE ANY SIDE EFFECTS?

Platelet rich therapy involves the injection of some substance beneath the skin. Hence, there is bound to be side effects. Platelet rich plasma is autologous. The implication is that it contains substances sourced from within your own body. The risk for allergic reactions are reduced. Of course, injection of other substances such as hyaluronic acid or cortisone can cause allergic reactions. On the other hand, the risk associated with the injection itself include:

  • Nerve injuries
  • Infections
  • Tissue damage
  • Pain at the site of the injection

The patient is advised to discuss these risks with his or her physician so that steps may be taken to reduce these risks.

 

PRP is applied in the following specialties:

  • Orthopedics and traumatology
  • Angiology
  • Stomatology and Maxillofacial surgery
  • Sport Medicine
  • Ophthalmology
  • Dermatology
  • Plastic Surgery
  • General Surgery

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REFERENCES

  • Aschwanden C. (2014). Platelet-rich plasma treatment is popular for sports injuries, whether it works or not.
    washingtonpost.com/national/health-science/platelet-rich-plasma-treatment-is-popular-for-sports-injuries-whether-it-works-or-not/2014/07/14/b6293b10-0607-11e4-a0dd-f2b22a257353_story.html?utm_term=.1882a99e0e89
  • Johnson C. (2013). Some hair loss patients turn to PRP.
    abc7news.com/archive/9346887/
  • Khatu S, et al. (2014). Platelet-rich plasma in androgenic alopecia: Myth or an effective tool? DOI:
    10.4103/0974-2077.138352
  • Platelet-rich plasma (PRP). (2011).
    orthoinfo.aaos.org/topic.cfm?topic=A00648
  • Platelet-rich plasma (PRP) therapy. (n.d.).
    emoryhealthcare.org/orthopedics/prp-therapy.html
  • Raeissadat R, et al. (2015). Knee osteoarthritis injection choices: Platelet-rich plasma (PRP) versus hyaluronic acid (a one-year randomized clinical trial). DOI:
    10.4137/CMAMD.S17894
  • Wesner M, et al. (2016). A pilot study evaluating the effectiveness of platelet-rich plasma therapy for treating degenerative tendinopathies: A randomized control trial with synchronous observational cohort. DOI:
    10.1371/journal.pone.0147842

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Basics: Bioidentical Hormone Replacement Therapy

BIOIDENTICAL HORMONE REPLACEMENT THERAPY

Overview

General functions of the body are controlled and regulated by two major systems – the nervous system and the hormonal system. The nervous system regulates the body’s functions through nervous signals while the hormonals system works with hormones. The hormones facilitate communication between cells in the body. They regulate most body functions including growth, immune function, libido, appetite, and even digestion. Hence, if the hormones are not balanced, then it may impact negatively on your health and general well-being.

In many cases, when the hormones become unbalanced, people resort to hormone replacement therapies – the aim being to ease the symptoms. An example of such therapy that has garnered attention recently is the bioidentical hormone replacement therapy (BHRT). The goal of this therapy is to solve hormonal issues naturally. But actually, what does bioidentical hormone therapy entail? What is it all about? Read on to find out.

Photo Credit: The Menopause Center

What is bioidentical hormone replacement therapy?

Bioidentical hormone replacement therapy as the name implies is a form of therapy administered for the purpose of maintaining optimal hormone levels.

The level of hormone in our bodies decline as we get older. Because of this, some drastic changes occur in the body including weight gain, fatigue and low energy levels, insomnia and other sleeping disorders, and low sex drive. These symptoms are alleviated by BHRT resulting in a reduced risk of diseases associated with old age.

What’s more? Hormone replacement therapy helps in reducing chronic ailments such as osteoporosis, heart disease, stroke, cancer and senility. Of course these diseases are usually associated with old age.

Also worthy of mention is the fact that bioidentical hormones are synthesized from plant estrogen. This compound has a similar chemical composition to that produced by the human body. Testosterone, estrogen and progesterone are among the hormones that are usually synthesized and used in the therapy. Bioidentical hormone replacement therapy can be done via the following forms:

  • Patches
  • Pills
  • Gels
  • Creams
  • Injections

What are the components of bioidentical hormone replacement therapy?

Production of most bioidentical hormones are done by pharmaceutical firms. Also, compounded bioidentical hormones are made on demand according to the physician’s orders. The process by which the compound is made is referred to as compounding. Ingredients used in compounding are usually altered or combined to suit an individual’s needs.

Certain bioidentical hormones have been approved by the United States Food and Drug Administration (FDA). Among these are progesterone and estriol. Estriol is a less potent form of estrogen. That said, no custom-made bioidentical hormone has been approved by the FDA.

Some unethical pharmaceutical firms have made it a practice to produce bioidentical hormones without taking some important factors such as purity, quality or safety controls into consideration. This is why some medical organizations are against the marketing and use of bioidentical hormones not approved by regulatory agencies.

Custom-made bioidentical hormones are said to be safe and more effective than the synthesized ones. However, the FDA and some physicians are totally against this, claiming that these have not been verified by scientific studies, and could prove dangerous to the user.

 

Comparing traditional and bioidentical hormones

Bioidentical hormones are not the same as those used in traditional hormone replacement therapy. The reason for this is that they have a similar chemical structure to the hormones produced naturally by the body. They are also produced from plant estrogens. Conversely, traditional hormones are produced from synthetic hormones and urine of pregnant horses.

Proponents of bioidentical hormones believe in the safety and efficacy of their products because, according to them, they are natural and have a close identity to the naturally-produced hormones. Experts are of the opinion that bioidentical hormone replacement therapy and HRT share similar risks. The risks posed by compounded bioidentical hormones may be greater. However, there’s not much research to show that bioidentical hormone replacement therapy has a greater efficacy than HRT.

 

What do users stand to benefit from bioidentical hormone replacement therapy?

Bioidentical hormone replacement therapy is mostly used in people who are aged or have a low hormone level. Women approaching menopause or who are already in menopause benefit greatly from this. It boost the levels of hormone that is below normal. It also improves moderate or severe symptoms of menopause including:

  • Night sweats
  • Hot flashes
  • Mood swings
  • Weight gain
  • Loss of memory
  • Sleep disorders
  • Low sex drive or pain during sexual intercourse.

Alongside alleviating the symptoms, hormone replacement therapy also minimizes the risk of cataracts, tooth loss and diabetes. Studies have shown that bioidentical hormone replacement therapy may assist with and help improve elasticity, hydration, thickness, and wrinkles.

For people whose estrogen level has been affected by cancer treatments, bioidentical hormone replacement therapy helps to improve their quality of life and general well-being. A study has shown that cancer patients who had a bioidentical hormone replacement therapy experienced a relief from symptoms such as incontinence, insomnia, low sex drive and migraines. These symptoms were related to cancer treatment. It was also discovered that the rate of breast cancer recurrence was below average.

 

Is it associated with any risks or side effects?

The FDA has approved a few bioidentical preparations of progesterone and estradiol. However, no compounded bioidentical hormone has been approved. It is said that bioidentical hormones have a higher safety level and effectiveness than the conventional HRT because their chemical structure is identical to that produced in the body. However, this has not been verified by reputable clinical studies. Hence, caution should be the watchword while using these products.

Studies have shown that the risks of some ailments may be increased by hormone replacement therapy. These ailments include:

  • Stroke
  • Blood clots
  • Breast cancer
  • Heart disease and
  • Gallbladder disease

Bioidentical hormone replacement therapy may also have certain side effects especially at the initial stage of usage. These include:

  • Bloating
  • Weight gain
  • Acne
  • Mood swings
  • Facial hair in ladies

Some people are allergic to bioidentical hormone replacement therapy or hormonal replacement of any form. Risks and side effects vary depending on the medical history of the individual involved. Individuals who intend to use this must consult their physician. He or she will then outline the pros and cons of usage before you adopt any form of it.

 

Bioidentical hormone replacement therapy treatment plan

  • The first step taken is to visit the healthcare professional. There, the patient discusses his or her medical history with the physician. The benefits of bioidentical hormone replacement therapy will be evaluated.
  • The next step will be testing of hormone levels in the serum
  • Thereafter, a follow-up consultation is done to discuss the test results and of course draw a plan of treatment.
  • The doctor then writes the hormone prescriptions while emphasizing on the importance of compliance.
  • Therapy starts
  • Serum testing is done at intervals to ensure that hormones are at their optimal levels
  • Regular checkup is done to ensure that results are at par with what was expected. If there is need for any changes, this will also be done.

 

 

Conclusion

Bioidentical hormone replacement therapy may be used by individuals who have symptoms linked to unbalanced or low hormonal levels. We have discussed the side effects and risk associated with bioidentical hormone replacement therapy. Users are advised to be wary of this and discuss with their physician.  Women in particular are advised to use this only on recommendation.  If it must be used, then only the lowest dose should be used.

 

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Consultation

Our initial consultation will determine which treatments are best for you. Next, we'll answer all your questions, dispel any myths and educate on stem cell treatments before we start.

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Once we have learned about your pain, we'll customize all of our treatments to your exact needs and ensure you're on your way to living a life without the pain and discomfort of arthritis.

References

  • Bioidentical hormones. (2014).
    my.clevelandclinic.org/health/articles/bioidentical-hormones
  • Bioidentical hormones: Help or hype? (2011).
    health.harvard.edu/womens-health/bioidentical-hormones-help-or-hype
  • Bio-identicals: Sorting myths from facts. (2017).
    wayback.archive-it.org/7993/20171101171029/https://www.fda.gov/ForConsumers/ConsumerUpdates/ucm049311.htm
  • Laughlin-Tommaso SK. (2014). Menopause hormone therapy: Who shouldn’t take it?
    mayoclinic.org/diseases-conditions/menopause/expert-answers/avoiding-menopause-hormone-therapy/faq-20115091
  • Sattari R. (n.d.). Conditions treated by bioidentical hormone replacement therapy.
    newjerseyhormonedoctor.com/conditions-treated/
  • Wiley TS. (2015). Bio-identical hormones replacement therapy and the quality of life for breast cancer patients. DOI:
    10.1200/jco.2015.33.28_suppl.87
  • Woolston C. (2010). Are bioidentical hormones safe?
    aarp.org/health/drugs-supplements/info-11-2010/are_bioidentical_hormones_safe.html

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Ozone Therapy Basics

OZONE THERAPY

Overview

The term ozone therapy describes the process where the ozone gas is administered into the body, the purpose of which is to treat a wound or a disease.  The ozone gas is uniquely colorless and consists of three oxygen atoms (O3).  It find great clinical applications through stimulation of immune functions. It is also employed in the disinfection and treatment of diseases. Clinically, ozone therapy gas is produced from clinical-grade oxygen sources.

Photo credit: Spa in Spain 

Everyone has experienced ozone in one way or the other

You may have noticed at some point that the air around you emits a fresh, poignant odor after a thunderstorm. The fragrance seems to be a familiar one but unfortunately, you have never been able to place it. The fragrance is similar to the one perceived at waterfalls and ocean waves, as well as when the fields of snow are hit by sunlight. The smell perceived is that of ozone, a natural gas. However, it isn’t only nature that can produce this substance. With advancements in science and technology, this gas can be produced at will. Artificial ozone has the exact characteristics as that produced naturally.

The ozone gas is a cleansing gas; this explains why one has the feeling of cleansing wherever around it. Ozone cleanses the atmosphere. When we are exposed to this gas, it also cleanses our bodies.

The question goes – why does the weatherman use such a dismal, dire tone to pronounce the ozone count? Why are the elderly advised not to jog? Why are the sick advised not to even step outside? Why is the high ozone count attributed to car emissions?

The reason for this is that ozone is produced not only by natural phenomena but also by pollution. Ozone is formed when moisture, temperature and sunlight interacts with pollutants. Thee pollutants are mainly hydrocarbons formed from carbon dioxide, nitrogen oxide, and carbon monoxide, and also from the partial combustion of fuel in car engines.

It suffice to say that the concentration of ozone is highly dependent on the level of pollution in that region. However, what we have not been told is that ozone helps in cleansing and without it, the level of pollution in our cities would be greater than normal.

Despite its not-so-pleasing reputation, ozone has become an interesting subject in medical research due to its potential healing effects – the ozone therapy.

The ozone therapy is quite versatile. This is because it can be utilized both medically and at home. The ozone therapy can be administered into various body organs, and through the skin. It can also be administered to damaged body parts and painful body parts.

According to a 2004 review of ozone therapy:

“During the past decade, contrary to all expectations, it has been demonstrated that the judicious application of ozone in chronic infectious diseases, vasculopathies, orthopedics and even dentistry has yielded such striking results that it is deplorable that the medical establishment continues to ignore ozone therapy.”1

Right from its inception, ozone therapy has proven useful against a number of ailments and afflictions including liver disease, cancer, viral diseases, auto-immune disorder, geriatric conditions, AIDS and SARS, Lyme disease, allergies, macular degeneration and cardiovascular diseases.

 

How does the ozone therapy work?

The ozone therapy interrupts harmful processes taking place in the body. It also inhibits the growth and development of bacteria that poses a threat to optimum health. For instance, a person who has an infection on some part of the body can stop its spread with ozone therapy. Studies have shown that ozone therapy is effective in the treatment of infections caused by:

  • Viruses
  • Bacteria
  • Protozoa
  • Fungi
  • Yeast

Ozone therapy also helps to expel the infected cells from the body. Once these cells are eradicated, new ones are produced by the body.

 

 

What conditions can be treated by ozone therapy?

The ozone therapy can treat many conditions. These include:

 

Respiratory disorders

People with respiratory disorders benefit greatly from ozone therapy. Ozone therapy loads the blood with oxygen thus minimizing the stress on the lungs. We know that the lungs are responsible for supply of oxygen to the blood.

Currently, clinical trials are ongoing for people with chronic obstructive pulmonary disease and asthma.

 

Diabetes

Research has also shown that ozone therapy helps combat the complications of diabetes. Diabetic complications arise due to oxidative stress in the body. Because ozone therapy supplies fresh oxygen to the blood, it is evident that diabetic patients could have a better prognosis. Diabetic patients usually have poor wound healing. Research has however shown that ozone therapy can help in skin and tissue repair.

 

Immune disorders

People suffering from immune disorders can benefit greatly from ozone therapy because it helps to stimulate the immune system. A 1991 study showed that ozone therapy can cause a complete inactivation of the HIV. However, there is need for more research to verify the efficacy of ozone therapy in HIV treatment.

 

Preparing for ozone therapy

The best preparation for ozone therapy is made by consulting your physician or healthcare provider. Your healthcare provider may give the therapy by mixing the ozone gas with blood drawn from your body. The blood is then reinjected into your system.

It is advisable that patients sleep well the night prior to the therapy. On the day of the therapy, do well to eat a healthy breakfast. Also hydrate by drinking enough water.

 

The treatment

Ozone therapy can be administered by a number of ways. Your healthcare provider will draw up the plan that best suits your condition and body system. That said, ozone therapy may be given in three ways:

Direct administration to the tissue: If you are undergoing the therapy for an injury a problem with your extremities, then the gas will be administered directly to the affected tissue. Administration is done in a protective covering.

Intravenous administration: When treating disorders that occur internally, the ozone gas will be dissolved in the blood extracted from the recipient’s body. The blood is then injected back into the body through an intravenous administration.

Intramuscular administration: Ozone therapy can also be administered intramuscularly. Here, the ozone gas is mixed in sterile water or the recipient’s blood before administration.

 

How effective is ozone therapy?

There have been mixed results from studies on ozone therapy. However, most studies have yielded promising results. Many clinical trials are ongoing for most ailments ranging from HIV to arthritis.

One trial showed that a new ozone therapy medication could be very effective in treating people with cystic fibrosis and chronic obstructive pulmonary disease. Studies are also ongoing on subjects with knee arthritis and other inflammatory disorders. No results have been released for now. It is also believed that people suffering back pain from herniated discs will also derive positive benefits from ozone therapy.

 

Are there any side effects?

Many health facilities are not using ozone therapy at this time, and some risks are associated with its usage. The gas does not have an even number of atoms, thus resulting in its unstable nature. This makes it unpredictable.

Great caution is applied by healthcare providers when using the ozone therapy. Red blood cells are at risk of damage when exposed to high concentrations of oxygen, hence measurements must be done precisely.

Consult your physician about the possible side effects and compare them with the potential benefits. You are also advised to checkout other treatment alternatives to help chose the best plan of treatment for your condition.

 

 

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References

  • Ben-Gurion University of the Negev. (2017). Intraarticular ozone therapy for pain control in osteoarthritis of the knee.
    clinicaltrials.gov/ct2/show/NCT00832312
  • Bocci V, et al. (2015). Validity of oxygen-ozone therapy as integrated medication form in chronic inflammatory diseases.
    ingentaconnect.com/content/ben/chddt/2015/00000015/00000002/art00012
  • Elvis AM, et al. (2011). Ozone therapy: A clinical review.
    ncbi.nlm.nih.gov/pmc/articles/PMC3312702/
  • Fuccio C, et al. (2009). A single subcutaneous injection of the ozone prevents allodynia and decreases the over-expression of pro-inflammatory caspases in the orbito-frontal cortex of neuropathic mice. DOI:
    10.1016/j.ejphar.2008.11.060
  • Johansson E, et al. (2009). Antibacterial effect of ozone on cariogenic bacterial species. DOI:
    10.1016/j.jdent.2009.02.004
  • Mayo Clinic. (2017). Blood donation.
    mayoclinic.org/tests-procedures/blood-donation/basics/how-you-prepare/prc-20020069
  • Revotar Biopharmaceuticals AG. (2017). Study to Evaluate the effect of bimosiamose on ozone induced sputum neutrophilia.
    clinicaltrials.gov/ct2/show/NCT00962481
  • Vinnik IS, et al. (2015). The results of combined ozone therapy using in complex treatment of soft tissues infections in patients with diabetes mellitus type II.
    europepmc.org/abstract/med/26031822
  • Wells KH, et al. (1991). Inactivation of human immunodeficiency virus type 1 by ozone in vitro.
    bloodjournal.org/content/bloodjournal/78/7/1882.full.pdf
  • Zhang J, et al. (2014). Increased growth factors play a role in wound healing promoted by noninvasive oxygen-ozone therapy in diabetic patients with foot ulcers. DOI:
    dx.doi.org/10.1155/2014/273475
  • GlaxoSmithKline. (2017). Evaluate the effects of the drug (SB-656933-AAA) on the body after a single dose in subjects who have inhaled ozone.
    clinicaltrials.gov/ct2/show/study/NCT00551811
  • Kovacs Foundation. (2017). The effect of ozone therapy for lumbar herniated disc.
    clinicaltrials.gov/ct2/show/NCT00566007

 

 

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Intravenous Vitamin Therapy Basics

INTRAVENOUS VITAMIN THERAPY

What is intravenous vitamin therapy?

Intravenous vitamin therapy is getting more popular by the day. It involves the direct administration of minerals and vitamins into the general circulation. The trend is very popular among celebrities. Intravenous vitamin therapy is recommended by Alternative therapy clinics for various diseases and ailments including hypertension, cancer, asthma, chronic obstructive pulmonary disorder, diabetes, hepatitis, chronic fatigue syndrome, depression, fibromyalgia, macular degeneration and Parkinson’s disease. Some health facilities believe that intravenous vitamin therapy boosts energy levels, enhances the functioning of the immune system, and helps the individual to cope with sleep disorder, jetlag and stress. Proponents and administrators of intravenous vitamin therapy prepare the injections according to individual requirements. One well-known formula however is the ‘Myer’s Cocktail’. This formula is made of high concentration of magnesium, B and C vitamins. It is believed that this formula treats numerous clinical conditions, ranging from asthmatic attacks to cardiovascular ailments. According to the Rothfield Center, “By directly administering nutrients to the body higher than normal blood levels can be achieved. These increased levels can provide an immediate therapeutic response by correcting deficiencies that may arise from a disease state.”

That said, we should note that there are no clinical researches to show that intravenous vitamin therapy impact positively on the user’s health, hence the short or long-term impact of this therapy is not known. If a person’s nutritional status is not as optimal level, then it may be a pointer to an inappropriate overall diet, which should be the starting point. With very little exceptions, we humans can get most of the vitamins and minerals required for proper functioning from a healthy diet. However, in some cases, there may be need for modest supplements of specific nutrients. For instance, pregnant women or those in the process of conceiving are recommended to take 400 micrograms of folic acid per day. This is done to prevent defects of the neural tube. Children below five years of age may take vitamins A, C and D; while those above 65 years of age may take 10 micrograms of D vitamin each day. These supplements are usually administered orally.

What happens to the body during an intravenous vitamin therapy?

Dr. John Myers developed the first intravenous vitamin drips in the 1970s. The result of his research was the well-known Myer’s Cocktail. Administration is usually done within the Physician’s office and takes anywhere from 20 minutes to one hour. While the infusion takes place, the concentration of the vitamin increases within the body. A vitamin that is administered orally is metabolized within the digestive tract, and the quantity that can be absorbed is very limited (50%). If the vitamin is administered intravenously, then a larger percentage is absorbed (up to 90%).

To explain it better, a person receiving an IV vitamin therapy receives a fluid mixture of minerals and vitamins via a tube into his or her vein. Doing so facilitates easy and quick absorption of the vitamins into the general circulation. This method causes a rise in the level of vitamins and minerals in the recipients body compared to if they were gotten from supplements or food. The reason for this is that food absorption is regulated by several factors in the body. These include the health status of the individual, age, genetics, metabolism, and the chemical and physical composition of the food or supplement. Higher concentrations of minerals and vitamins in the bloodstream enhances cellular uptake of the nutrients. Theoretically, the cells use these nutrients to combat illness and maintain health.

Intravenous vitamin therapy have been prescribed and administered by qualified physicians and nurses over the years. This is a fast way to deliver medication or fluids into the body’s system. During an intravenous vitamin treatment, the pharmacist mixes the solution according to the physician’s prescriptions. The healthcare administrator will first locate the vein before inserting the needle securely in it. If the patient is dehydrated, it may take several attempts to get it right. Thereafter, the professional will monitor the infusion to be sure that the vitamins or minerals are properly administered.

What are the risks involved?

Studies have shown that vitamins and minerals when taken in excess may prove dangerous to the body. This is can be seen in cases of fat soluble vitamins and minerals that are stored but not excreted by the body. For instance, administration of vitamin A in large quantities can cause damage to the bone and the liver while vitamin E at high doses can interfere with the absorption of other body vitamins. Of great concern is the fact that most health facilities that administer these vitamins do not ask for nor have past medical records of their patients. As such, they are not aware of any underlying medical condition or contraindications. Users of intravenous vitamin therapy may receive excess of these nutrients, resulting in health implications. This is especially so if the nutrients are administered on a daily basis. As the saying goes, too much of everything isn’t good, and for this reason, optimum levels for oral administration of minerals and vitamins have been established, taking into consideration the absorbed proportions, and the fact that it may vary between individuals. However, it is understood that some individuals can tolerate better excess nutrients compared to others. For instance, iron in excess quantities may be stored, resulting in a condition called hemochromatosis.

Injection of substances into the blood comes with attendant risks like air bubbles that can transfer to the general circulation. Other risks include infections and allergic reactions. These are likely to occur if the administration is not properly done. Presently, regulatory bodies do not exist to govern the safety in such clinics. Intravenous administration of vitamins should be done only by qualified professionals.

References

Gaby AR (2002) Intravenous Nutrient Therapy: the “Myers’ Cocktail”. Alternative Medicine Review 7 (5): 389 – 403

NHS Choices (2014) Vitamin B12 or folate deficiency anaemia – Treatment. Available at: http://www.nhs.uk/Conditions/Anaemia-vitamin-B12-and-folate-deficiency/Pages/Treatment.aspx

The Rothfield Centre (2014) IV Nutrient Infusion Therapy. Available at: http://rothfeldcenter.com/about/vitamin-infusion-therapy/

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